Abstract
Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are hormones important for satiation and are involved in the process called "ileal brake". The aim of this study was to investigate the GLP-1- and PYY-stimulating efficacy of rebaudioside A, casein, and sucrose. This was studied using tissue segments collected from various regions of the pig small intestine. GLP-1 release was strongest from the distal ileum. There, control release was 0.06 ± 0.01 (GLP-1) and 0.07 ± 0.01 (PYY) pmol/cm(2) of tissue. Rebaudioside A (2.5, 12.5, and 25 mM) stimulated GLP-1 release (0.14 ± 0.02, 0.16 ± 0.02, and 0.13 ± 0.02 pmol/cm(2) of tissue, p <0.001) and PYY release (0.19 ± 0.02, 0.42 ± 0.06, and 0.27 ± 0.03 pmol/cm(2) of tissue, p <0.001). Sucrose stimulated GLP-1 release (0.08 ± 0.01 pmol/cm(2) of tissue, p <0.05) only at 10 mM. Casein (0.5%, 1%, and 2.5%, w/v) stimulated GLP-1 release (0.15 ± 0.03, 0.13 ± 0.02, and 0.14 ± 0.01 pmol/cm(2) of tissue, p <0.001) and PYY release (0.13 ± 0.02, 0.20 ± 0.03, and 0.27 ± 0.03 pmol/cm(2) of tissue, p <0.01). These findings may help in developing dietary approaches for weight management.
Original language | English |
---|---|
Pages (from-to) | 8365-8370 |
Number of pages | 6 |
Journal | Journal of Agricultural and Food Chemistry |
Volume | 62 |
Issue number | 33 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- enteroendocrine cell-line
- nutrient-driven satiety
- hormone-release
- taste receptor
- glp-1 release
- fatty-acids
- food-intake
- secretion
- gut
- sweeteners
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Ripken, D., van der Wielen, N., Wortelboer, H. M., Meijerink, J., Witkamp, R. F., & Hendriks, H. F. (2014). Steviol glycoside rebaudioside A induces glucagon-like peptide-1 and peptide YY release in a porcine ex vivo intestinal model. Journal of Agricultural and Food Chemistry, 62(33), 8365-8370. https://doi.org/10.1021/jf501105w
Ripken, D. ; van der Wielen, N. ; Wortelboer, H.M. et al. / Steviol glycoside rebaudioside A induces glucagon-like peptide-1 and peptide YY release in a porcine ex vivo intestinal model. In: Journal of Agricultural and Food Chemistry. 2014 ; Vol. 62, No. 33. pp. 8365-8370.
@article{b65d1a2d80f741cea4d27d08360142a2,
title = "Steviol glycoside rebaudioside A induces glucagon-like peptide-1 and peptide YY release in a porcine ex vivo intestinal model",
abstract = "Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are hormones important for satiation and are involved in the process called {"}ileal brake{"}. The aim of this study was to investigate the GLP-1- and PYY-stimulating efficacy of rebaudioside A, casein, and sucrose. This was studied using tissue segments collected from various regions of the pig small intestine. GLP-1 release was strongest from the distal ileum. There, control release was 0.06 ± 0.01 (GLP-1) and 0.07 ± 0.01 (PYY) pmol/cm(2) of tissue. Rebaudioside A (2.5, 12.5, and 25 mM) stimulated GLP-1 release (0.14 ± 0.02, 0.16 ± 0.02, and 0.13 ± 0.02 pmol/cm(2) of tissue, p <0.001) and PYY release (0.19 ± 0.02, 0.42 ± 0.06, and 0.27 ± 0.03 pmol/cm(2) of tissue, p <0.001). Sucrose stimulated GLP-1 release (0.08 ± 0.01 pmol/cm(2) of tissue, p <0.05) only at 10 mM. Casein (0.5%, 1%, and 2.5%, w/v) stimulated GLP-1 release (0.15 ± 0.03, 0.13 ± 0.02, and 0.14 ± 0.01 pmol/cm(2) of tissue, p <0.001) and PYY release (0.13 ± 0.02, 0.20 ± 0.03, and 0.27 ± 0.03 pmol/cm(2) of tissue, p <0.01). These findings may help in developing dietary approaches for weight management.",
keywords = "enteroendocrine cell-line, nutrient-driven satiety, hormone-release, taste receptor, glp-1 release, fatty-acids, food-intake, secretion, gut, sweeteners",
author = "D. Ripken and {van der Wielen}, N. and H.M. Wortelboer and J. Meijerink and R.F. Witkamp and H.F. Hendriks",
year = "2014",
doi = "10.1021/jf501105w",
language = "English",
volume = "62",
pages = "8365--8370",
journal = "Journal of Agricultural and Food Chemistry",
issn = "0021-8561",
publisher = "American Chemical Society",
number = "33",
}
Ripken, D, van der Wielen, N, Wortelboer, HM, Meijerink, J, Witkamp, RF & Hendriks, HF 2014, 'Steviol glycoside rebaudioside A induces glucagon-like peptide-1 and peptide YY release in a porcine ex vivo intestinal model', Journal of Agricultural and Food Chemistry, vol. 62, no. 33, pp. 8365-8370. https://doi.org/10.1021/jf501105w
Steviol glycoside rebaudioside A induces glucagon-like peptide-1 and peptide YY release in a porcine ex vivo intestinal model. / Ripken, D.; van der Wielen, N.; Wortelboer, H.M. et al.
In: Journal of Agricultural and Food Chemistry, Vol. 62, No. 33, 2014, p. 8365-8370.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Steviol glycoside rebaudioside A induces glucagon-like peptide-1 and peptide YY release in a porcine ex vivo intestinal model
AU - Ripken, D.
AU - van der Wielen, N.
AU - Wortelboer, H.M.
AU - Meijerink, J.
AU - Witkamp, R.F.
AU - Hendriks, H.F.
PY - 2014
Y1 - 2014
N2 - Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are hormones important for satiation and are involved in the process called "ileal brake". The aim of this study was to investigate the GLP-1- and PYY-stimulating efficacy of rebaudioside A, casein, and sucrose. This was studied using tissue segments collected from various regions of the pig small intestine. GLP-1 release was strongest from the distal ileum. There, control release was 0.06 ± 0.01 (GLP-1) and 0.07 ± 0.01 (PYY) pmol/cm(2) of tissue. Rebaudioside A (2.5, 12.5, and 25 mM) stimulated GLP-1 release (0.14 ± 0.02, 0.16 ± 0.02, and 0.13 ± 0.02 pmol/cm(2) of tissue, p <0.001) and PYY release (0.19 ± 0.02, 0.42 ± 0.06, and 0.27 ± 0.03 pmol/cm(2) of tissue, p <0.001). Sucrose stimulated GLP-1 release (0.08 ± 0.01 pmol/cm(2) of tissue, p <0.05) only at 10 mM. Casein (0.5%, 1%, and 2.5%, w/v) stimulated GLP-1 release (0.15 ± 0.03, 0.13 ± 0.02, and 0.14 ± 0.01 pmol/cm(2) of tissue, p <0.001) and PYY release (0.13 ± 0.02, 0.20 ± 0.03, and 0.27 ± 0.03 pmol/cm(2) of tissue, p <0.01). These findings may help in developing dietary approaches for weight management.
AB - Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are hormones important for satiation and are involved in the process called "ileal brake". The aim of this study was to investigate the GLP-1- and PYY-stimulating efficacy of rebaudioside A, casein, and sucrose. This was studied using tissue segments collected from various regions of the pig small intestine. GLP-1 release was strongest from the distal ileum. There, control release was 0.06 ± 0.01 (GLP-1) and 0.07 ± 0.01 (PYY) pmol/cm(2) of tissue. Rebaudioside A (2.5, 12.5, and 25 mM) stimulated GLP-1 release (0.14 ± 0.02, 0.16 ± 0.02, and 0.13 ± 0.02 pmol/cm(2) of tissue, p <0.001) and PYY release (0.19 ± 0.02, 0.42 ± 0.06, and 0.27 ± 0.03 pmol/cm(2) of tissue, p <0.001). Sucrose stimulated GLP-1 release (0.08 ± 0.01 pmol/cm(2) of tissue, p <0.05) only at 10 mM. Casein (0.5%, 1%, and 2.5%, w/v) stimulated GLP-1 release (0.15 ± 0.03, 0.13 ± 0.02, and 0.14 ± 0.01 pmol/cm(2) of tissue, p <0.001) and PYY release (0.13 ± 0.02, 0.20 ± 0.03, and 0.27 ± 0.03 pmol/cm(2) of tissue, p <0.01). These findings may help in developing dietary approaches for weight management.
KW - enteroendocrine cell-line
KW - nutrient-driven satiety
KW - hormone-release
KW - taste receptor
KW - glp-1 release
KW - fatty-acids
KW - food-intake
KW - secretion
KW - gut
KW - sweeteners
U2 - 10.1021/jf501105w
DO - 10.1021/jf501105w
M3 - Article
SN - 0021-8561
VL - 62
SP - 8365
EP - 8370
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 33
ER -
Ripken D, van der Wielen N, Wortelboer HM, Meijerink J, Witkamp RF, Hendriks HF. Steviol glycoside rebaudioside A induces glucagon-like peptide-1 and peptide YY release in a porcine ex vivo intestinal model. Journal of Agricultural and Food Chemistry. 2014;62(33):8365-8370. doi: 10.1021/jf501105w